Synthesis of 1-methoxy-2-indanone

Synthesis of 1-methoxy-2-indanone Ex. 1 As chief scientific incumbent of Mark, Inc. R&D, I have the responsibility of reviewing proposed syntheses for untried drugs that our company wishes to develop. Our president has identify 1-methoxy-2-indanone as a desire target, and two groups in our R&D discussion section have proposed syntheses for this molecule. After mensurable evaluation, I have selected the synthesis from Research host A as the one to the highest degree likely to achieve success. Two steps in the marriage proposal from Research Group B have problems that allow sheath those steps, and hence the boilers suit synthesis, to fail. In step 1, the use of Br2 in the presence of FeBr3 will result in bromination of the aromatic mobilize to induce 5-bromoindane or else than 1-bromoindane. Had Br2 in the presence of ultraviolet put down been employed instead, the reply would likely have succeeded to give the sought after 1-bromoindane. Each of the conterminous three steps from group B would give the verbalise product from the say moveant, although I do not pick up why group B would expect to prepare indane-1,2-dione (the stated product from step 4). Certainly, the net step would not get 1-methoxy-2-indanone from indane-1,2-dione.

Lithium aluminum hydride is a powerful reducing agent, and two ketone groups would be reduced to alcohols to give 1,2-dihydroxyindane as the final product. Furthermore, the protic solving methanol is likely to react with LiAlH4 as well. All-in-all, step 5 would be a messy reaction. I respectfully disagree with our president that 1-methoxy- 2-indanone is a advantageously candidate fo! r synthesis. many another(prenominal) over-the-counter NSAIDs such as aspirin, ibuprofen, and naproxen contain carboxyl acid groups, and our target molecule does not. I strongly progress research group A to action a essential literature search prior to investiture the time, effort, and material be needed to synthesize 1-methoxy-2-indanone. In addition, I... If you want to get a full essay, order it on our website: BestEssayCheap.com

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